Phosphonic acid substituted aromatic steroids as inhibitors...

Details Phosphonic acid substituted aromatic steroids as inhibitors... Phosphonic acid substituted aromatic steroids as inhibitors...

C - Chemistry, Metallurgy

07

J

167/191, 260/56,

C07J 41/00 (2006.01) A61K 31/56 (2006.01) C07J 43/00 (2006.01) C07J 51/00 (2006.01)

Patent

CA 2004946

ABSTRACT OF THE DISCLOSURE PHOSPHONIC ACID SUBSTITUTED AROMATIC STEROIDS AS INHIBITORS OF STEROID 5-.alpha.-REDUCTASE Invented are phosphonic acid substituted analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase, including using these compounds to reduce or maintain prostate size. Also invented are intermediates used in preparing these compounds.

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