Phosphonic diester derivative

Details Phosphonic diester derivative Phosphonic diester derivative

C - Chemistry, Metallurgy

07

F

C07F 9/547 (2006.01) A61K 31/675 (2006.01) C07F 9/58 (2006.01) C07F 9/6512 (2006.01)

Patent

CA 2184891

A phosphonic diester derivative represented by general formula (1) and useful as a remedy and preventive for hyperlipidemia, hypertension and diabetes. (see fig. I) In formula (1) R1, R2, R3 and R6 are the same or different and each represents a hydrogen atom, a lower alkyl group, a halogen atom, a nitro group, a lower alkoxy group, a cyano group, a phenylsulfonylamino group, a benzoylamino group, an amino group or a halogen-substituted lower alkyl group; R4 represents a phenyl group, a lower alkyl group, a phenyl(lower)alkyl group optionally substituted by halogen on the phenyl ring, a lower alkenyl group, a carboxy(lower)alkyl group, a (lower)alkoxy-carbonyl (lower)alkyl group, a (lower)alkoxy(lower)alkyl group, a lower alkynyl group, a benzoyl(lower)alkyl group, an amino group, a di(lower)alkanoylamino group, a benzylideneamino group optionally having lower alkoxy on the phenyl ring or a pyridylmethylideneamino group; R5 represents a lower alkyl group; R7 represents a lower alkoxy group, a hydroxyl group, a phenyl group, a phenyl(lower)alkoxy group optionally having halogen on the phenyl ring or a phenyl(lower)alkylamino group; X1 and X2 independently represent an oxygen atom or a sulfur atom; A represents an oxygen atom or a single bond; and Z represents a lower alkylene group.

L'invention concerne un dérivé de diester phosphonique représenté par la formule générale (I) et utile pour traiter et prévenir, entre autres, l'hyperlipidémie, l'hypertension, le diabète. Dans cette formule, R<1>, R<2>, R<3> et R<4> représentent chacun séparément hydrogène, alkyle inférieur, halogène, nitro, etc.; R<4> représente phényle, alkyle inférieur, phénylalkyle, etc.; R<5> représente alkyle inférieur; R<7> représente alcoxy inférieur, hydroxy, phényle, ou alkylamino inférieur ou alcoxy inférieur phénylé, le groupe phényle pouvant être halogéné; X<1> et X<2> représentent chacun oxygène ou soufre; A représente oxygène ou une liaison simple; et Z représente alkylène inférieur.

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