Phosphonomethoxytetrahydrofuranyl-purine/pyrimidine derivatives

C - Chemistry – Metallurgy – 07 – H

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195/139, 167/202

C07H 19/06 (2006.01) A61K 31/675 (2006.01) A61K 31/70 (2006.01) C07D 473/00 (2006.01) C07F 9/547 (2006.01) C07H 21/00 (2006.01)

Patent

CA 2015671

Compounds of the following formulas which have anti-tumor and anti-viral activity and are especially useful in treating viral infections, their compositions and use. A phosphonomethoxymethyoxymethyl purine/pyrimidine derivative of the formula Image wherein X and X' are the same or different and are hydrogen or alkyl. R and R' are the same or different and are hydrogen, alkyl, hydroxyalkyl or R"CO-where R" is an alkyl and B is a purine or pyrimidine base. A 4'-phosphonomethoxytetrahydrofuranyl-1'-purine-pyrimidine of the formula Image wherein X and X' are the same or different and are hydrogen or alkyl, Y and Z are the same of different and are hydrogen hydroxyl or alkyl or Y + Z is an alkenyl, an epoxide or cyclopropyl, and B is a purine or pyrimidine base.

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