Phosphonomonoester nucleic acids, process for their...

Details Phosphonomonoester nucleic acids, process for their... Phosphonomonoester nucleic acids, process for their...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 31/70 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01) C07F 9/40 (2006.01) C07H 21/00 (2006.01) C07K 2/00 (2006.01) C07K 14/00 (2006.01)

Patent

CA 2171589

Novel oligonucleotide analogs of the formula (I) are described, (see formula I) in which A, B, D, G, L, P, Q, Q', R5, R6, X, Y, Z and n are as defined in the description, which have useful physical, biological and pharmacological properties, as well as a process for their preparation. Their application relates to use as inhibitors of gene expression (antisense oligonucleotides, ribozymes, sense oligonucleotides and triplex-forming oligonucleotides), as probes for the detection of nucleic acids and as auxiliaries in molecular biology.

Dans l'invention, on décrit de nouveaux analogues d'oligonucléotide présentant la formule (I) (voir formule I), dans laquelle A, B, D, G, L, P, Q, Q', R5, R6, X, Y, Z et n sont définis comme il est mentionné dans la description. Ces analogues ont des propriétés physiques, biologiques et pharmacologiques utiles. On décrit également un procédé de préparation. Concernant leur application, on peut les utiliser comme inhibiteurs de l'expression génique (oligonucléotides antisens, ribozymes, oligonucléotides sens et oligonucléotides formant un triplex), sondes pour détecter des acides nucléiques et réactifs en biologie moléculaire.

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