Phosphoramidate derivatives of nucleoside compounds for use...

Details Phosphoramidate derivatives of nucleoside compounds for use... Phosphoramidate derivatives of nucleoside compounds for use...

C - Chemistry, Metallurgy

07

H

C07H 19/20 (2006.01) A61K 31/7076 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01)

Patent

CA 2602324

Phosphoramidate derivatives of nucleoside compounds such as cladribine, isocladribine, fludaribine and clofarabine have enhanced therapeutic potency in homo sapiens, in particular, enhanced potency with respect to a cancer such as leukaemia. Suitably the phosphoramidate is substituted at the P atom by Ar- O, where Ar is aryl or heteroaryl, either of which may be optionally substituted. Formula (I).

La présente invention concerne des dérivés de phosphoramidate de composés de nucléoside, tels que la cladribine, l'isocladribine, la fludaribine et la clofarabine qui ont amélioré le pouvoir thérapeutique chez l'homo sapiens, plus particulièrement en ce qui concerne un cancer, tel que la leucémie. Par ailleurs, le phosphoramidate est substitué au niveau de l'atome P par Ar-O, où Ar désigne un aryle ou un hétéroaryl, l'un ou l'autre pouvant être éventuellement substitué. (I).

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