Phosphoramidite reagent for chemical synthesis of modified dna

Details Phosphoramidite reagent for chemical synthesis of modified dna Phosphoramidite reagent for chemical synthesis of modified dna

C - Chemistry, Metallurgy

07

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260/229, 195/1.2

C07H 19/12 (2006.01) C07H 1/02 (2006.01) C07H 19/04 (2006.01) C07H 21/00 (2006.01) C07H 21/04 (2006.01)

Patent

CA 1330960

ABSTRACT OF THE DISCLOSURE 5,6-dihydro-5-azacytidine phosphoramidite is useful in the synthesis of oligonucleotides and DNA con- taining dihydro-5-aza- and 5-azacytosine bases. The modified oligonucleotides which contain 5-azacytosine residues at specific sites can be used to determine the mechanism of selective gene activation and the relation- ship existing between the presence of the triazine base and inhibition of DNA methylation.

595701

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