Phosphoribosyl pyrophosphate synthetase 1 as herbicidal target

Details Phosphoribosyl pyrophosphate synthetase 1 as herbicidal target Phosphoribosyl pyrophosphate synthetase 1 as herbicidal target

C - Chemistry, Metallurgy

12

N

C12N 15/00 (2006.01) C12N 9/12 (2006.01) C12N 15/82 (2006.01) C12Q 1/48 (2006.01)

Patent

CA 2401177

The invention relates to the use of DNA sequences of plant origin, coding for a polypeptide with phosphoribosyl pyrophosphate synthetase 1 (E.C. 2.7.6.1) activity, for the discovery of phosphoribosyl pyrophosphate synthetase 1 inhibitors. The demonstration of phosphoribosyl pyrophosphate synthetase 1 as a herbicidal target by means of anti-sense technology is novel.

La présente invention concerne l'utilisation de séquences d'ADN d'origine végétale codant un polypeptide ayant une activité de synthétase 1 de pyrophosphate de phosphoribosyle (E.C. 2.7.6.1), dans la fabrication d'un système de test servant à détecter des inhibiteurs de la synthétase 1 de pyrophosphate de phosphoribosyle. Pour la première fois, il a été possible de montrer au moyen de la technologie antisens que la synthétase 1 de pyrophosphate de phosphoribosyle représente une cible herbicide.

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