Phosphoric diesters

Details Phosphoric diesters Phosphoric diesters

C - Chemistry, Metallurgy

07

F

167/244, 260/356

C07F 9/12 (2006.01) A61K 31/665 (2006.01) C07F 9/6558 (2006.01)

Patent

CA 1269669

Abstract of the disclosure: There is disclosed a novel phosphoric diesters of general formula: Image [wherein R1 and R2 are the same or different and each means a methyl group or a hydrogen atom, provided that at least one of R1 and R2 is a hydrogen atom, or a salt thereof] which can be produced by reacting .beta., .gamma. or .delta.- tocopherol with a halophosphorylating agent such as phos- phorus oxychloride, reacting the resultant product with ascorbic acid whereof hydroxyl groups at 5- and 6-posi- tions are protected, and then removing protected groups from the hydroxyl groups. The phosphoric diester has antiinflammatory activity.

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