C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
260/501, 260/468
C07F 9/30 (2006.01) C07F 9/32 (2006.01) C07F 9/38 (2006.01) C07F 9/40 (2006.01)
Patent
CA 1223266
A B S T R A C T Compounds having the general formula Image in which W is R1 or OR1, R1 being hydrogen, alkyl, phenyl or benzyl X is -(CH2)p-CHR3 or CHR3-(CH2)p- R33 is chosen from various substituents, Y is Image , Image , Image , or Image , Z is chosen from various of organic groups, and R2 forms, with the carbonyl group to which it is attached, carboxy or various esterified carboxy groups or is the group -NR8R9. The compounds inhibit the activity of enkephalinases. Intermediates of formula Image are disclosed in which Wa is alkoxy, phenoxy or benzyloxy Xa is Image , and Ya is -NH2 or -NCO.
445993
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Schering Corporation
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