Phosphorus containing cythesine derivatives

Details Phosphorus containing cythesine derivatives Phosphorus containing cythesine derivatives

C - Chemistry, Metallurgy

07

F

C07F 9/6561 (2006.01) A61K 31/675 (2006.01)

Patent

CA 2233632

Synthesized recently phosphorus containing cethysine derivatives in general formula (I) have been stated, where n=0, 1; at n=0 X=S; R=CH3; C2H5; C3H7; 1=C3H7; C4H9 at n=1 X=0, R=CH3, R1=1-C3H7; C6H5; n-CH3O-. It has been shown that some of the synthesized compounds display high hepatoprotective and antienzyme activity.

Dérivés phosphorés de cytisine récemment obtenus par synthèse, et répondant à la formule générale (I), dans laquelle n vaut 0 ou 1. Lorsque n vaut 0, alors X représente S, R représente CH¿3? ou C¿2?H¿5?, ou C¿3?H¿7?; 1 représente C¿3?H¿7? ou C¿4?H¿9?. Lorsque n vaut 1, alors X représente O, R représente CH¿3?, et R?1¿ représente 1-C¿3?H¿7?, C¿6?H¿5? ou n-CH¿3?O-. On a mis en évidence que certains de ces composés de synthèse présentent une importante activité hépatoprotectrice et anti-enzyme.

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