Phosphorus containing peptides

Details Phosphorus containing peptides Phosphorus containing peptides

C - Chemistry, Metallurgy

07

K

167/103.05, 530/

C07K 5/06 (2006.01) C07F 9/40 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1322076

Abstract Novel compounds of the formula (I), a process for their preparation and their use as collagenase inhibitors are described: Image (1) in which R1 is hydrogen or hydroxy; R2 is hydrogen or alkyl; R3 is C3-6 alkyl; R4 is hydrogen, alkyl, -CH2-Z where Z is optionally substituted phenyl or heteroaryl, or R4 is a group Image where R8 is hydrogen, alkyl or -CH2-Ph where Ph is optionally substituted phenyl, and R9 is hydrogen or alkyl; and R5 is hydrogen or alkyl.

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