Phosphorylated c-erbb2 as a superior predictive theranostic...

Details Phosphorylated c-erbb2 as a superior predictive theranostic... Phosphorylated c-erbb2 as a superior predictive theranostic...

G - Physics

01

N

G01N 33/574 (2006.01)

Patent

CA 2729796

The present invention provides reliable methods to identify subsets of subjects with a cancer of epithelial origin characterized by a high level of phosphorylated c-erbB2 which does not correlate with the over-expression of total c-erbB2 as measured by IHC or FISH, for selection and inclusion for c-erbB2-direct treatment and therapy. Furthermore, the present invention provides a reliable method to determine whether a subject with a cancer of epithelial origin who has been determined to be c-erbB2 positive by IHC and by FISH should be excluded from c-erbB2-direct treatment because of a non-significant level of phosphorylated c-erbB2 in epithelial tumor tissue.

La présente invention porte sur des procédés fiables d'identification de sous-ensembles de sujets présentant un cancer d'origine épithéliale, caractérisé par un niveau élevé de c-erbB2 phosphorylé, ne présentant pas de corrélation avec la surexpression du c-erbB2 total telle que mesurée par IHC ou FISH, pour sélection et inclusion dans le cadre d'un traitement et d'une thérapie dirigés sur du c-erbB2. En outre, la présente invention porte sur un procédé fiable pour déterminer si un sujet présentant un cancer d'origine épithéliale, qui s'est avéré être c-erbB2 positif par une IHC ou une FISH, devrait être ou non exclu d'un traitement dirigé sur du c-erbB2 en raison d'un niveau non significatif de c-erbB2 phosphorylé dans le tissu tumoral épithélial.

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