C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) A61K 39/395 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C12Q 1/48 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01) G01N 33/58 (2006.01)
Patent
CA 2456010
The present invention is directed to the generation of antibodies against an .alpha.-phosphorylated serine 14 residue on Histone 2B. This postranslational modification of the amino terminus of Histone 2B is associated with cells that are about to enter or are already undergoing apoptosis. These antibodies are useful in identifying apoptotic cells and serve as diagnostic and screening tools. The present invention is also directed to the Mst1 kinase and the isolation of compounds that modulate the activity of Mst1. This kinase has been identified as the enzyme responsible for creating this postranslational modification on Histone 2B in vivo.
La présente invention concerne la production d'anticorps dirigés contre un résidu de sérine 14 alpha-phosphorylée sur l'histone 2B. Cette modification post-traductionnelle de l'aminé terminal de l'histone 2B est associée à des cellules sur le point d'entrer en apoptose ou en cours d'apoptose. Ces anticorps sont utiles pour l'identification de cellules apoptotiques et servent d'outils de diagnostic et de criblage. L'invention concerne en outre la Mst1 kinase et l'isolement de composés qui modulent l'activité de Mst1. Cette kinase a été identifiée comme l'enzyme à l'origine de cette modification post-traductionnelle <i>in vivo</i> de l'histone 2B.
Ajiro Kozo
Allis C. David
Cheung Wang L.
Sim & Mcburney
University Of Virginia Patent Foundation
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