A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/665 (2006.01) C07F 9/655 (2006.01)
Patent
CA 2693338
The invention relates to phosphorylated polyphenols, phosphorylated flavonoids, and phosphorylated pyrone analogs. Methods and compositions for the modulation of side effects of substances using such phosphorylated compounds are described Methods and compositions are described for the modulation of blood- tissue barrier (BTB) transporter activity to increase the efflux of drugs and other compounds out of a physiological compartment and into an external environment In particular, the methods and compositions disclosed herein provide lowered side effects when phosphorylated pyrone analogs are coadministered with therapeutic agents
L'invention concerne des polyphénols phosphorylés, des flavonoïdes phosphorylés et des analogues de pyrone phosphorylés. Des procédés et compositions pour la modulation des effets secondaires de substances utilisant de tels composés phosphorylés sont décrits. Des procédés et compositions sont décrits pour la modulation de l'activité du transporteur de la barrière sang-tissu (BTB) pour augmenter le flux sortant de médicaments et d'autres composés hors d'un compartiment physiologique et à l'intérieur d'un environnement externe. En particulier, les procédés et compositions révélés ici assurent un abaissement des effets secondaires lorsque des analogues de pyrone phosphorylés sont coadministrés avec des agents thérapeutiques.
Lee Ving
Robbins Wendye
Gowling Lafleur Henderson Llp
Limerick Biopharma Inc.
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