Phosphotyrosine assay and peptides for use therein

Details Phosphotyrosine assay and peptides for use therein Phosphotyrosine assay and peptides for use therein

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) C07K 7/08 (2006.01) C07K 14/52 (2006.01) C07K 14/71 (2006.01) C07K 14/72 (2006.01) C12N 9/12 (2006.01) G01N 33/566 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2208318

This invention relates to an assay for molecules capable of interacting with cytokine receptor intracellular peptides, and to peptides suitable for use in said assay. The peptides correspond to tyrosine-containing regions of the sequence of an intracellular domain of a cytokine, a hormone receptor or a JAK Protein Tyrosine Kinase, and comprise a tyrosine which is able to be phosphorylated. In phosphorylated form, the peptides are able to bind cytoplasmic transcription factors of the STAT family.

L'invention concerne un procédé de détection de moléculles capables d'exercer une interaction avec des peptides intracellulaires du récepteur de cytokine, ainsi que les peptides pouvant être utilisés dans ledit procédé. Ces peptides correspondent à des régions contenant tyrosine de la séquence d'un domaine intracellulaire d'une cytokine, d'un récepteur d'hormone ou d'une tyrosine kinase de protéine de la famille JAK et comprennent une tyrosine capable d'être phosphorylée. Sous la forme phosphorylée, ces peptides peuvent se fixer à des facteurs de transcription cytoplasmique de la famille STAT.

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