Phosphotyrosine mimics and methods for identifying and using...

Details Phosphotyrosine mimics and methods for identifying and using... Phosphotyrosine mimics and methods for identifying and using...

C - Chemistry, Metallurgy

07

C

C07C 271/22 (2006.01) A61K 31/27 (2006.01) A61K 38/02 (2006.01) A61K 38/07 (2006.01) C07K 5/113 (2006.01) C07K 16/18 (2006.01) C07K 16/40 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2253776

This invention relates to phosphotyrosine mimics which, when incorporated into an appropriate molecular structure, are capable of inhibiting the binding of tyrosine kinase-dependent regulatory proteins to the native phosphotyrosine- containing receptors. This invention also relates to methods and kits for identifying and using phosphotyrosine mimics. The compounds, kits and methods of this invention are useful for identifying and designing antagonists of tyrosine-kinase dependent regulatory proteins, such as signal transduction proteins containing SH2 binding domains.

Cette invention concerne des mimétiques de phosphotyrosine qui, lorsqu'on les incorpore dans une structure moléculaire appropriée, sont capables d'inhiber la liaison des protéines de régulation dépendant de la tyrosine-kinase aux récepteurs naturels contenant de la phosphotyrosine. Cette invention concerne également des procédés et des trousses permettant d'identifier et d'utiliser des mimétiques de phosphotyrosine. Les composés, les trousses et les procédés de cete invention sont utiles pour identifier et désigner des antagonistes de protéines de régulation dépendant de la tyrosine-kinase telles que des protéines de transduction de signal contenant des domaines de liaison SH¿2?.

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