Phosphyorylated fusion proteins and uses related thereto

Details Phosphyorylated fusion proteins and uses related thereto Phosphyorylated fusion proteins and uses related thereto

C - Chemistry, Metallurgy

07

K

C07K 14/555 (2006.01) A61K 49/00 (2006.01) G01N 33/60 (2006.01)

Patent

CA 2360128

Modified proteins, modified interferons .alpha.'s and .beta.'s, phosphorylated modified proteins and DNA sequences encoding the above, applications and uses thereof. Modified phosphorylated Hu- IFN-.alpha.-like proteins are provided which carry an identifiable label such as a radio-label. Corresponding phosphorylatable Hu-IFN-.alpha.- like proteins which contain a putative phosphorylation site. DNA sequences which encode a Hu-IFN-.alpha.-like protein and contain a sequence encoding a putative phosphorylatable site. Appropriate expression vectors are used to transform compatible host cells of various microorganisms, such as E. coli. Numerous uses for the phosphorylated proteins are disclosed.

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