C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 19/00 (2006.01) A61K 31/706 (2006.01) C07H 19/06 (2006.01) C07H 19/16 (2006.01)
Patent
CA 2556829
The present invention relates to novel phosponate nucleosides, more specifically to novel phosponalkoxy substituted nucleosides. The invention further relates to compounds having HIV (Human Immunodeficiency Virus) replication inhibiting properties and to compounds having antiviral activities with respect to other viruses. The invention also relates to methods for preparation of all such compounds and pharmaceutical compositions comprising them. The invention further relates to the use of said compounds as a medicine and in the manufacture of a medicament useful for the treatment of subjects suffering from HIV infection, as well as for treatment of other viral, retroviral or lentiviral infections and to the treatment of animals suffering from FIV, viral, retroviral or lentiviral infections.
L'invention concerne des nouveaux nucléosides phosphonates, plus spécifiquement des nouveaux nucléosides à substitution phosphonalcoxy. L'invention porte également sur des composés possédant des propriétés d'inhibition de la réplication du VIH (virus de l'immunodéficience humaine) et sur des composés possédant des activités antivirales par rapport à d'autres virus. L'invention se rapporte encore à des méthodes de préparation de tous lesdits composés et à des compositions pharmaceutiques les comprenant. Elle concerne aussi l'utilisation desdits composés en tant que médicaments, et dans la fabrication d'un médicament utile pour le traitement de sujets souffrant d'une infection à VIH, ainsi que pour le traitement d'autres infections virales, rétrovirales ou lentivirales et pour le traitement d'animaux souffrant d'infections à FIV, virales, rétrovirales ou lentivirales.
de Clercq Erik
Herdewijn Piet
Pannecouque Christophe
Wu Tongfei
K.u. Leuven Research & Development
Smart & Biggar
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