Photoactivated crosslinking of a protein or peptide

C - Chemistry – Metallurgy – 08 – H

Patent

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Details

C08H 1/00 (2006.01) A61L 15/32 (2006.01) A61L 15/58 (2006.01) A61L 24/10 (2006.01) A61L 27/44 (2006.01) C09J 189/00 (2006.01)

Patent

CA 2696255

A method of crosslinking a protein or peptide for use as a biomaterial, the method comprising the step of irradiating a photoactivatable metal-ligand complex and an electron acceptor in the presence of the protein or peptide, thereby initiating a crosslinking reaction to form a 3-dimensional matrix of the biomaterial.

L'invention porte sur un procédé de réticulation d'une protéine ou d'un peptide destiné à être utilisé comme biomatériau. Le procédé consiste à irradier un complexe métal-ligand photoactivable et un accepteur d'électrons en présence de la protéine ou du peptide, ce qui permet d'amorcer une réaction de réticulation afin de former une matrice tridimensionnelle du biomatériau.

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