Photoactivation of proteins for conjugation purposes

Details Photoactivation of proteins for conjugation purposes Photoactivation of proteins for conjugation purposes

C - Chemistry, Metallurgy

07

K

C07K 1/113 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/08 (2006.01) A61K 51/10 (2006.01) B01J 19/12 (2006.01) C07K 1/107 (2006.01) G01N 33/531 (2006.01) G01N 33/534 (2006.01)

Patent

CA 2137561

A protein containing one or more disulfide bonds, e.g., an antibody, is subjected to ultraviolet radiation to reduce one or more such bonds to reactive sulfhydryl groups; the resulting photoactivated protein is reacted with other chemical entity which is reactive with sulfhydryl, such as certain radiometals, chelating agents, drugs and toxins, so as to obtain a conjugate useful in, e.g., in vitro diagnosis, in vivo imaging, and therapy.

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