C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/87 (2006.01) A61K 31/00 (2006.01) A61K 39/00 (2006.01) A61K 41/00 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2430087
The present invention provides a method for introducing a molecule into the cytosol of a cell in which the cell is contacted with a photosentistising agent, the cell is irradiated with light of a wavelength effective to activate the photosentisitising agent and, substantially at the same time or after the irradiation, the cell is contacted with the molecule to be introduced, particularly for use in cancer treatment, gene therapy and vaccination.
La présente invention concerne un procédé permettant d'introduire une molécule dans le cytosol d'une cellule. Ce procédé consiste à mettre en contact une cellule avec un agent photosensibilisant, à irradier la cellule au moyen d'une lumière présentant une longueur d'ondes permettant d'activer l'agent photosensibilisant et, sensiblement en même temps ou après l'irradiation, à mettre en contact la cellule avec la molécule à introduire. Ce procédé peut être mise en oeuvre en particulier dans le traitement du cancer, la thérapie génique et la vaccination.
Berg Kristian
Hogset Anders
Prasmickaite Lina
Selbo Pal Kristian
Fetherstonhaugh & Co.
Pci Biotech As
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