C - Chemistry – Metallurgy – 08 – B
Patent
C - Chemistry, Metallurgy
08
B
C08B 37/08 (2006.01) A61L 15/28 (2006.01) A61L 27/20 (2006.01) A61L 31/04 (2006.01) C08J 3/28 (2006.01)
Patent
CA 2237192
A photocured cross-linked-hyaluronic acid gel, which has a storage modulus (G') of from 50 to 1500 Pa, a loss modulus (G") of from to 300 Pa, and a tangent delta (G"/G') of from 0.1 to 0.8 in dynamic viscoelasticity at a frequency of 10 Hz, and which is a hydrogel obtained by irradiation with ultraviolet rays of a photoreactive hyaluronic acid derivative in which a photoreactive cross-linking group is chemically linked to a functional group of the hyaluronic acid and cross- linking of mutual photoreactive cross-linking groups, methods for preparing the same, and uses thereof as biomedical materials.
La présente invention concerne un gel d'acide hyaluronique réticulé photopolymérisable, qui a un module de conservation (G') allant de 50 à 1500 Pa, un module de perte (G'') de 10 à 300 Pa et une tangente delta (G''/G') de 0 à 0,8 en viscoélasticité dynamique à une fréquence de 10 Hz, et qui est un hydrogel obtenu, par irradiation aux rayons ultraviolets, à partir d'un dérivé d'acide hyaluronique photoréactif lié chimiquement à un groupe fonctionnel de l'acide hyaluronique. L'invention concerne également la réticulation de groupes de réticulation mutuellement photoréactifs. L'invention concerne aussi des procédés de préparation de ces produits et des utilisations comme substances biomédicales.
Miyamoto Kenji
Waki Michinori
Riches Mckenzie & Herbert Llp
Seikagaku Corporation
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