C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 17/00 (2006.01) A61K 39/395 (2006.01) A61K 41/00 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61P 35/00 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C07K 17/08 (2006.01)
Patent
CA 2445898
The present invention relates to photosensitizer immunoconjugate compositions and combination therapies for use in cancer related photodynamic treatments and diagnostic methods. Photosensitizer immunoconjugates comprising a photosensitizer conjugated to a tumor-specific and/or tumoricidal antibody and processes for the preparation thereof are described. The use of photosensitizer immunoconjugates (PICs) offers improved photosensitizer delivery specificity for diagnostic and therapeutic applications. Combination therapies to co-localize activated photosensitizer compounds and tumoricidal antibodies in tumor tissues are also described.
L'invention concerne des compositions d'immunoconjugués de photosensibilisant et des thérapies de combinaison utilisées dans des traitements photodynamiques du cancer; et des méthodes de diagnostic. L'invention concerne également des immunoconjugués de photosensibilisant (PIC) comprenant un photosensibilisant conjugué à un anticorps spécifique d'une tumeur et/ou tumoricide et des procédés de préparation desdits immonoconjugués. L'utilisation des PIC offre une spécificité de distribution de photosensibilisant améliorée pour des applications diagnostiques et thérapeutiques. L'invention concerne enfin des thérapies de combinaison permettant de localiser simultanément des composés de photosensibilisant activés et des anticorps tumoricides dans des tissus tumoraux.
Hasan Tayyaba
Savellano Mark D.
Skobe Mihaela
Mbm Intellectual Property Law Llp
The General Hospital Corporation
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