Photoluminescent heterodiamondoids as biological labels

G - Physics – 01 – N

Patent

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G01N 21/76 (2006.01)

Patent

CA 2533154

Novel biological labels are disclosed herein. The label comprises a functionalized heterodiamondoid functioning as a biological probe, the probe having an affinity for a target analyte molecule. Upon absorption of incident excitation radiation, color center(s) located within the heterodiamondoid are caused to luminesce. The photoemitted light may be detected and analyzed to yield information about the analyte. The color centers in the heterodiamondoid will typically comprise nitrogen-vacancy and/or nitrogen-pore complexes, but may also comprise a dopant impurity atom such as a rare earth or transition metal element.

La présente invention a trait à de nouvelles étiquettes biologiques. L'étiquette comporte un hétérodiamantoïde fonctionnant comme une sonde biologique, la sonde présentant une affinité pour une molécule d'analyte cible. Lors de l'absorption de rayonnement d'excitation incident, un/des centre(s) situé(s) au sein de l'hétérodiamantoïde deviennent luminescent(s). La lumière d'émission photoélectrique peut être détectée et analysée pour fournir une information concernant l'analyte. Les centres colorés dans l'hétérodiamantoïde va, de manière caractéristique, comprendre de complexes azote/vides et/ou azote/pores, mais peuvent également comprendre un atome d'impureté dopante tel qu'une terre rare ou un élément de métal de transition.

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