Photosensitizer functionalised nanoparticles

Details Photosensitizer functionalised nanoparticles Photosensitizer functionalised nanoparticles

A - Human Necessities

61

K

A61K 41/00 (2006.01) A61K 9/51 (2006.01) A61K 33/00 (2006.01) A61K 33/24 (2006.01) A61K 33/26 (2006.01) A61K 33/34 (2006.01) A61K 33/38 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2465401

The present invention relates to self-assembly of a photosensitiser on a nanoparticle. The invention also provides methods for production of functionalised (eg. stabilised) nanoparticles. The nanoparticles may be used in Photodynamic Therapy (PDT). the invention can provide, for example, self- assembled phthalocyanine monolayers (SAMs), wherein the monolayer is formed on a metallic nanoparticle. The term "metallic" as used herein refers to metals, metal oxides and other metal-containing compositions. According to the invention a functionalised nanoparticle comprises: a metallic core; a photosensitiser monolayer chemically bonded to said core, said monolayer containing molecules capable of photo-excitation to produce a reactive oxygen species such as singlet oxygen, from oxygen molecules; and a phase transfer reagent.

L'invention concerne l'assemblage automatique d'un photosensibilisant sur une nanoparticule. Elle concerne ~galement des proc~d~s servant ~ pr~parer des nanoparticules fonctionnalis~es (c'est-~-dire, stabilis~es). On peut utiliser ces nanoparticules en th~rapie photodynamique (PDT). L'invention peut concerner, par exemple, des monocouches de phtalocyanine assembl~es automatiquement (SAM), ladite monocouche ~tant cr~~e sur une nanoparticule m~tallique. Le terme "m~tallique" tel qu'il est utilis~, concerne des m~taux, des oxydes de m~taux ou d'autres compositions contenant des m~taux. Cette nanoparticule fonctionnalis~e est compos~e d'un noyau m~tallique, d'une monocouche de photosensibilisant poss~dant une liaison chimique avec ledit noyau, ladite monocouche contenant des mol~cules capables de photoexcitation afin de produire un type d'oxyg­ne r~actif, tel qu'un oxyg­ne singulet, ~ partir de mol~cules d'oxyg­ne, ainsi que d'un r~actif de transfert de phase.

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