Photosensitizers for photodynamic applications

Details Photosensitizers for photodynamic applications Photosensitizers for photodynamic applications

C - Chemistry, Metallurgy

07

D

C07D 487/22 (2006.01) A61K 41/00 (2006.01)

Patent

CA 2345580

A family of benzochlorin derivatives of formulas of Figs. 1A and 1B of the attached drawing are suitable for use as photosensitizers in photodynamic therapy. Solutions of the benzochlorin derivatives are physiologically accepted for selective destruction of cells and tissues. A method of destroying cells and tissues through a photodynamic process wherein a pharmaceutical composition including the benzochlorin derivates of formulas of Figs, 1A and 1B are administered to a human or animal patient and light sufficient to generate a cytotoxic effect is supplied.

L'invention concerne une famille de dérivés du chlorobenzène, dont les formules sont illustrées dans les figures (IA) et (IB), qui peuvent être utilisés comme photosensibilisants en thérapie photodynamique. Les solutions desdits dérivés de chlorobenzène, qui sont acceptées sur le plan physiologique, provoquent une destruction cellulaire et tissulaire sélective. L'invention concerne également un procédé qui permet de détruire les cellules et les tissus par une technique photodynamique, qui consiste à administrer à l'homme ou à l'animal les dérivés de chlorobenzène de formules (IA) et (IB), puis à exposer ledit animal ou homme à une lumière suffisante pour générer un effet cytotoxique.

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