Phthalazin-4-ylacetic acid derivatives

Details Phthalazin-4-ylacetic acid derivatives Phthalazin-4-ylacetic acid derivatives

C - Chemistry, Metallurgy

07

D

260/264.3, 260/2

C07D 237/30 (2006.01) C07D 237/32 (2006.01) C07D 307/88 (2006.01) C07D 491/04 (2006.01) C07D 493/04 (2006.01)

Patent

CA 1107732

ABSTRACT This invention relates to enzyme inhibitory, novel phthalazin-4-ylacetic acid derivatives of the general formula I:- Image I and pharmaceutically acceptable salts as appropriate, to pharmaceutical compositions thereof, and to analogy processes for their manufacture. The compounds of formula I are inhibitors of the enzyme aldose reductase in vivo and as such may be userul in the reduction or prevention of the development of the peripheral effects such as macular oedema, cataract, retinopathy or impared neural conduction. A preferred compound is 2-(2- fluoro-4-bromobenzyl)-1,2-dihydro-1-oxophthalazin- ?-ylacetic acid.

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