C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 237/32 (2006.01) C07D 237/30 (2006.01) C07D 237/34 (2006.01) C07D 413/12 (2006.01)
Patent
CA 2599403
The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A1, A2, B, R1, R2, R3 and R4 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.
L'invention concerne une classe de composés utiles dans la prophylaxie et le traitement de maladies induites par les protéines kinases, notamment des inflammations et des états relatifs. Les composés sont de formule générale I, dans laquelle A1, A2, B, R1, R2, R3 et R4 sont définis dans la description. L'invention concerne également des compostions pharmaceutiques renfermant un ou plusieurs composés de formule I, des utilisations de ces composés et compositions dans le traitement de maladies induites par les protéines kinases, notamment l'arthrite rhumatoïde, le psoriasis et d'autres troubles inflammatoires, des intermédiaires et des procédés utiles dans la préparation des composés de formule I.
Cao Guo-Qiang
Chakrabarti Partha Pratim
Falsey James Richard
Herberich Bradley J.
Hungate Randall W.
Amgen Inc.
Gowling Lafleur Henderson Llp
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