C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 237/30 (2006.01) A61K 31/501 (2006.01) A61P 29/00 (2006.01) C07D 237/34 (2006.01) C07D 403/10 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01) C07D 417/10 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2662148
The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A1, A2, B, R1, R2, R3 and R4 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.
La présente invention concerne une nouvelle classe de composés utilisables pour la prophylaxie et le traitement de maladies induites par la protéine-kinase, y compris l'inflammation et les affections apparentées. Les composés répondent à la formule générale (I) [INSÉRER LA STRUCTURE ICI] (I) dans laquelle A1, A2, B, R1, R2, R3 et R4 sont définis ici. L'invention concerne également des compositions pharmaceutiques qui comprennent un ou plusieurs composés de formule (I), l'utilisation de tels composés et de telles compositions pour le traitement de maladies induites par la protéine-kinase, y compris la polyarthrite rhumatoïde, le psoriasis et d'autres affections inflammatoires, ainsi que des intermédiaires et des procédés utilisables pour la préparation de composés de formule (I).
Chakrabarti Partha Pratim
Pettus Liping H.
Rzasa Robert M.
Sham Kelvin K.c.
Tasker Andrew
Amgen Inc.
Gowling Lafleur Henderson Llp
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