C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 237/32 (2006.01) A61K 31/502 (2006.01) A61K 31/5377 (2006.01) A61P 1/04 (2006.01) A61P 11/00 (2006.01) A61P 11/02 (2006.01) A61P 11/06 (2006.01) A61P 17/00 (2006.01) A61P 17/06 (2006.01) A61P 27/14 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01) C07D 401/10 (2006.01) C07D 403/10 (2006.01) C07D 413/10 (2006.01) C07D 491/113 (2006.01)
Patent
CA 2605383
It is intended to provide a novel compound having an excellent PDE4 inhibitory activity and TNF-.alpha. production-suppressing activity. It is also intended to provide a preventive and therapeutic agent for atopic dermatitis or the like. The invention comprises a novel phthalazinone derivative represented by the following general structural formula [1], a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same as an active ingredient. [Chemical formula 12] [1] In the structural formula [1], the following partial structure between positions 6 and 7 represents a single bond or a double bond. [Chemical formula 13] R1 and R2 represent alkyl or the like, Y represents phenylene or the like, Z represents alkylene or the like, R3 represents a mono- to tri-cyclic saturated or unsaturated cyclic amino group or the like and R31 and R32 represent alkyl or the like.
L'invention concerne un nouveau composé ayant une excellente activité inhibitrice de PDE4 et une excellente activité de suppression de la production de TNF-.alpha.. L'invention concerne également un agent préventif et thérapeutique pour la dermite atopique ou similaires. L'invention comprend un nouveau dérivé de phtalazinone représenté par la formule structurelle générale [1] suivante, un de ses sels pharmaceutiquement acceptables, et une composition pharmaceutique la contenant en tant qu'ingrédient actif. [Formule chimique 12] [1] Dans la formule structurelle [1], la structure partielle suivante entre les positions 6 et 7 représente une liaison simple ou double. [Formule chimique 13] R1 et R2 représentent un alkyle ou similaires, Y représente un phénylène ou similaires, Z représente un alkylène ou similaires, R3 représente un groupe amino cyclique mono- à tri-cyclique saturé ou insaturé ou similaires, et R31 et R32 représentent un alkyle ou similaires.
Kagayama Kohei
Zhang Xin
Fetherstonhaugh & Co.
Nippon Shinyaku Co. Ltd.
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