Phthalazinone derivatives

Details Phthalazinone derivatives Phthalazinone derivatives

C - Chemistry, Metallurgy

07

D

C07D 401/10 (2006.01) A61K 31/502 (2006.01) A61P 31/20 (2006.01) C07D 237/32 (2006.01) C07D 403/10 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2482806

A compound of formula (I); or an isomer, salt, solvate, chemically protected form, or prodrug thereof, wherein A and B together represent an optionally substituted, fused aromatic ring; RL is a C5-7 aryl group substituted in the meta position by the group R2, and optionally further substituted; wherein R2 is selected from formula (II) and formula (III); and its use as a pharmaceutical, in particular for the treatment of diseases ameliorated by inhibiting the activity of PARP.

L'invention concerne un composé de formule (I) ou un isomère, un sel, un solvate, une forme protégée chimiquement, ou un promédicamment de ce composé. Dans cette formule, A et B représentent ensemble un noyau aromatique fusionné ; R<SP>L</SP> est un groupe aryle C¿5-7 ?substitué dans la position meta par le groupe R?2¿, et portant éventuellement d'autres substituants ; où R?2¿ est sélectionné parmi (II) et (III). L'invention concerne également l'utilisation de ce composé en tant que médicament, en particulier dans le traitement de maladies amélioré par inhibition de l'activité de PARP.? ¿

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