Phthalazinone derivatives

Details Phthalazinone derivatives Phthalazinone derivatives

C - Chemistry, Metallurgy

07

D

C07D 237/32 (2006.01) A61K 31/00 (2006.01) A61K 31/502 (2006.01) A61P 31/20 (2006.01) C07D 401/10 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/10 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 471/20 (2006.01) C07D 491/04 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2517629

Compounds of the formula (I): wherein A and B together represent an optionally substituted, fused aromatic ring; X can be NRX or CRXRY; if X NRX then n is 1 or 2 and if X = CRXRY then n is 1; RX is selected from the group consisting of H, optionally substituted C1-20 alkyl, C5-20 aryl, C3-20 heterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups; RY is selected from H, hydroxy, amino; or RX and RY may together form a spiro-C3-7 cycloalkyl or heterocyclyl group; RC1 and RC2 are both hydrogen, or when X is CRX RY, RC1, RC2, RX and RY, together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; and R1 is selected from H and halo.

L'invention concerne des composés de formule (I): dans laquelle A et B représentent ensemble un noyau aromatique éventuellement substitué et fusionné; X peut désigner NR<SP>X</SP> ou CR<SP>X</SP>R<SP>Y</SP>; si X = NR<SP>X</SP> alors n prend la valeur de 1 ou 2 et si X = CR<SP>X</SP>R<SP>Y </SP>alors n prend la valeur de 1; R<SP>X</SP> est sélectionné dans le groupe comprenant H, C¿1-20? alkyle éventuellement substitué, C¿5-20? aryle, C¿3-20? hétérocyclyle, amido, thioamido, ester, acyle, et des groupes sulfonyle; R<SP>Y</SP> est sélectionné parmi H, hydroxy, amino; ou R<SP>X</SP> et R<SP>Y</SP> peuvent former ensemble spiro-C¿3-7? cycloalkyle ou un groupe hétérocyclyle; R<SP>C1</SP> et R<SP>C2</SP> représentent tous deux l'hydrogène ou quand X désigne CR<SP>X </SP>R<SP>Y</SP>, R<SP>C1</SP>, R<SP>C2</SP>, R<SP>X</SP> et R<SP>Y</SP>, conjointement avec les atomes de carbone auxquels ils sont fixés, ils peuvent former un noyau aromatique éventuellement substitué et fusionné; et R?1¿ est sélectionné parmi H et halo.

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