Phthalazone derivatives and process for preparing thereof

Details Phthalazone derivatives and process for preparing thereof Phthalazone derivatives and process for preparing thereof

C - Chemistry, Metallurgy

07

D

260/264.3

C07D 237/32 (2006.01)

Patent

CA 1089462

ABSTRACT OF THE DISCLOSURE This invention discloses novel phthalazone derivatives of the following general formula Image wherein R4 represents carbamoyl,dialylaminolkylcarbamoyl, hydroxyalkylcarbamoyl, alkylidenehydrazinocarbonyl, hydrazinocar- bonyl, alkylhydrazinocarbonyl, formyl, alkylhydrazonomethyl, hydroxyiminomethyl, dialkyldrazonemethyl, carbomoylhydrazono methyl, alkylidenehydrazonomethyl, hydrazonomethyl (-CH-NNH2), R6, R7 and R8 each represent alkyl and in the above representa- tion, every alkyl means lower alkyl, or salt thereof, and a process for their production. The novel compounds of the pxesent invention show particularly good antagonistic reaction to thromboxane A2(TXA2) and thus may be utilized for the treat- ment and prevention of cerebral apoplexy, myocardial infarction and similar conditions.

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