Phthalimide carboxylic acid derivatives

Details Phthalimide carboxylic acid derivatives Phthalimide carboxylic acid derivatives

C - Chemistry, Metallurgy

07

D

C07D 413/10 (2006.01) A61K 31/423 (2006.01) A61P 35/00 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2481307

The present invention relates to phthalimide carboxylic acid derivatives of formula (I), methods for their preparation, pharmaceutical compositions containing them and their use in medicine, specifically in the treatment of cancer. (I), wherein X is O or S; R1 is a phthalimide carboxylic acid group of formula (II). R is hydrogen, C1-C6 alkyl, aryl or C1-C3 alkylaryl and R2, R3 and R4 represent various substituents.

L'invention concerne des dérivés d'acides carboxyliques phtalimidiques de la formule (I), leurs procédés de préparation, des compositions pharmaceutiques les contenant et leur utilisation en médecine, notamment lors du traitement du cancer, dans laquelle X représente O ou S; R?1¿ représente un groupe d'acide carboxylique phtalimidique de la formule (II); R représente hydrogène, alkyle C¿1?-C¿6?, aryle ou alkylaryle C¿1?-C¿3?, R?2¿, R?3¿ et R?4¿ représentant divers substituants.

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