Physical trapping type polymeric micelle drug preparation

Details Physical trapping type polymeric micelle drug preparation Physical trapping type polymeric micelle drug preparation

A - Human Necessities

61

K

A61K 9/10 (2006.01) A61K 9/107 (2006.01) A61K 9/51 (2006.01) A61K 31/405 (2006.01) A61K 47/34 (2006.01) A61K 47/48 (2006.01) C08G 69/10 (2006.01)

Patent

CA 2104045

The present invention relates to drug carriers composed of a block copolymer having hydrophilic and hydrophobic segments, a polymeric micelle type drug comprising hydrophobic drugs trapped by physical treatments in said drug carrier and methods for trapping hydrophobic drugs in the drug carrier. The drugs carrier composed of the block copolymer according to the inven- tion forms a stable polymeric micelle structure with which hydrophobic drugs can be incorporated very efficiently via physical trapping. It was found that the incorporated drug is stably maintained in micelles even in the presence of serum. In addition, a drug difficult to administer into the living body owing to sparing water-solubility for its high hydrophobicity can be administered in the form of polymeric micelle drug.

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