Physiologic chemical method of labeling protein substances...

Details Physiologic chemical method of labeling protein substances... Physiologic chemical method of labeling protein substances...

A - Human Necessities

61

K

167/40

A61K 51/08 (2006.01) A61K 51/04 (2006.01)

Patent

CA 1245980

ABSTRACT OF DISCLOSURE A Novel chemical method of labeling plasma proteins, compounds and substances containing proteins with the radionuclides of Indium (In) at physiologic pH 6-8 condition producing an efficiently labeled radioactive tracer material suitable for biomedical and clinical applications. These radiolabeled protein substances are not denatured by the labeling process but retain their native physiobiochemical proper- ties. This novel labeling technique offers a simple and rapid means of labeling plasma proteins such as serum albumin, transferrin, lactoferrin, fibrinogen and immunoglobulins or antibodies with 111In or 113mIn for scintigraphic imaging which may allow visualization of thrombi, emboli, myocardial infarcts, infectious lesions, tumors or any vascular abnormalities in the body. - 1 -

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