Physiologically active peptide and its n-acyl derivatives...

Details Physiologically active peptide and its n-acyl derivatives... Physiologically active peptide and its n-acyl derivatives...

C - Chemistry, Metallurgy

12

P

530/5.02, 195/12

C12P 21/00 (2006.01) C07K 5/02 (2006.01) C12N 9/52 (2006.01) C12N 9/58 (2006.01) C12N 9/80 (2006.01)

Patent

CA 1040123

ABSTRACT OF THE DISCLOSURE The present invention relates to novel physiologically active N-acyl peptides of the general formula: R'-Val-X-Ala-X wherein R' is an acyl radical having 1 to 16 carbon atoms or said acyl radical partially substituted by one or more hydroxyl groups or phenoxy groups or halogen atoms, Val is L-valine, the X between Val and Ala is 4-amino-3-hydroxy-6-methylheptanoic acid and Ala is L-alanine, the other X is 4-amino-3-hydroxy-6-methylheptanoic acid or salt or an ester thereof and the amino group of Val being bound to said acyl radical by an amide bond, the carboxyl group of Val being bound to the amino group of the X between Val and Ala to form a peptide bond, the carboxyl group of the X between Val and Ala being bound to the amino group of Ala to form a peptide bond, the carboxyl group of Ala being bound to the amino group of the other X to form a peptide bond, and the carboxyl group of the other X being free or esterified or bound to a cation to form a salt,and a process for their preparation.

221066

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