Physiologically active peptides having bronchodilative and...

Details Physiologically active peptides having bronchodilative and... Physiologically active peptides having bronchodilative and...

C - Chemistry, Metallurgy

07

K

530/7.34

C07K 14/575 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1288894

ABSTRACT OF THE DISCLOSURE Novel peptides are disclosed having the structure: His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr- Arg-Leu-Arg-Lys-Gln-X-Ala-Val-Lys-Lys-Tyr-Leu- Asn-Ser-Ile Leu-Asn-Gly-Y wherein X is Met or Leu; and Y is OH, Lys-OH, Arg-OH, Lys- Arg-OH, or Lys-NH2 when X is Met, or Y is Lys-NH2, Lys-OH, or Lys-Arg-OH when X is Leu. The peptides exhibit bronchodilative activity and hypotensive activity.

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