Physiologically active polyoxypeptin and deoxypolyoxypeptin...

C - Chemistry – Metallurgy – 07 – K

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C07K 7/06 (2006.01) A61K 38/12 (2006.01) C12N 1/20 (2006.01) C12P 21/04 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2293828

Polyoxypeptin and deoxypolyoxypeptin represented by general formula (I): wherein R represents hydroxyl in the case of polyoxypeptin and hydrogen in the case of deoxypolyoxypeptin; which are novel substances having the activity of inducing apoptosis even on apoptosis-tolerant cells and obtained by culturing Streptomyces sp. MK498-98F12 strain. These compounds are physiologically active substances having the activity of inducing apoptosis on human hepatic cancer cells and AsPC-1 cells.

La présente invention concerne les polyoxypeptine et désoxypolyoxypeptine représentées par la formule générale (I), dans laquelle R représente un hydroxyle dans le cas de la polyoxypeptine et l'hydrogène dans le cas de la désoxypolyoxypeptine. Les polyoxypeptine et désoxypolyoxypeptine sont de nouvelles substances ayant une activité induisant l'apoptose même au niveau de cellules résistant à l'apoptose, obtenues par la culture des souches Streptomyces sp. MK498-98F12. Ces composés sont physiologiquement actifs et ont une activité induisant l'apoptose des cellules cancéreuses du foie humain et des cellules AsPC-1.

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