Physiologically active polypeptide conjugate having...

C - Chemistry – Metallurgy – 07 – K

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C07K 19/00 (2006.01) C07K 14/00 (2006.01) C07K 16/00 (2006.01)

Patent

CA 2519059

A protein conjugate having a prolonged in vivo half-life of a physiological activity, comprising i) a physiologically active polypeptide, ii) a non- peptidic polymer, and iii) an immunoglobulin, is useful for the development of a polypeptide drug due to the enhanced in vivo stability and prolonged half- life in blood, while reducing the possibility of inducing an immune response.

L'invention concerne un conjugué de protéine ayant une activité physiologique à demi-vie in vivo prolongée, qui renferme i) un polypeptide physiologiquement actif, ii) un polymère non peptidique, et iii) une immunoglobuline, utile pour l'élaboration d'un médicament polypeptidique par sa stabilité in vivo améliorée et sa demi-vie prolongée dans le sang, et réduisant simultanément le risque de l'induction d'une réponse immune.

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