C - Chemistry – Metallurgy – 08 – B
Patent
C - Chemistry, Metallurgy
08
B
C08B 37/00 (2006.01) A61K 31/70 (2006.01) A61K 39/385 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) C07H 15/04 (2006.01) C08B 31/00 (2006.01) C08G 73/10 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2111129
Abstract of the Disclosure The invention relates to physiologically tolerated and physiologically degradable polymer-based carbohydrate receptor blockers with an HLB* of 10 to 20 containing: carbohydrate portion - bifunctional spacer - hydrophilic, biodegradable polymer - potentiator, where the carbohydrate portion which is composed of 1 to 20 naturally occurring, identical or different, monosaccharide units is coupled via one or more bifunctional spacers, which is a natural or synthetic molecule, to a hydrophilic, biodegradable polymer, where the polymer in turn is the carrier of one or more spacers, and the hydrophilic, biodegradable polymer is additionally linked to the potentiator which is a crosslinker, one or more groups with hydrophobic, hydrophilic or ionic properties or a solubility improver, to a process for the preparation and to their use in vivo for blocking carbohydrate-recognizing receptors. The carbohydrate receptor blocker causes no intolerance reaction in vivo either in its entirety or in the form of degradation products.
Ahlers Michael
Bartnik Eckhart
Grabley Susanne
Kretzschmar Gerhard
Schleyerbach Rudolf
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Kretzschmar Gerhard
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