Phytomics: a genomic-based approach to herbal compositions

Details Phytomics: a genomic-based approach to herbal compositions Phytomics: a genomic-based approach to herbal compositions

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2373708

The present invention provides the tools and methodologies necessary to guide the standardization of herbal compositions, to determine which specific components of an herbal composition are responsible for any particular biological activity, to predict the biological activities of a particular herbal composition, to determine the relatedness of herbal compositions, and for the development of improved herbal therapeutics. This invention provides the tools and methodologies for creating, maintaining, improving and utilizing Herbal BioResponse Arrays (HBR Arrays), wherein the HBR Arrays constitute data sets associated with particular herbal compositions. The HBR Arrays of the present invention contain gene expression profiles and may also include information on the plant-related parameters of the herbal constituents, marker information collected following the exposure of a biosystem to the herbal composition, and biological response information collected following the exposure of a biosystem to the herbal composition.

L'invention concerne des outils et méthodologies nécessaires pour orienter la normalisation de compositions à base de plantes, afin de déterminer les composants spécifiques d'une telle composition qui sont responsables d'une activité biologique particulière, de prévoir ses activités biologiques, de déterminer le rapprochement entre les compositions à base de plantes, et d'élaborer de meilleures thérapies faisant intervenir des plantes. Cette invention propose des outils et méthodologies permettant de créer, d'actualiser, d'améliorer et d'exploiter des réseaux HBR (réseaux de réponse biologique faisant intervenir des plantes), qui constituent des ensembles de données associés à des compositions particulières à base de plantes. Ces réseaux HBR, qui contiennent des profils d'expression génique, peuvent comprendre des informations relatives aux paramètres liés aux plantes des constituants à base de plantes, ainsi que des informations sur les marqueurs et sur la réponse biologique recueillies à la suite de l'exposition d'un écosystème à la composition à base de plantes.

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