Pi 3-kinase inhibitors and methods of their use

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 401/14 (2006.01) A61K 31/5377 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2675558

Phosphatidylinositol (PI) 3-kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases, including proliferative diseases, inflammatory and obstructive airways diseases, allergic conditions, auutoimmune and cardiovascular diseases.

L'invention concerne des composés inhibiteurs de la phosphatidylinositol (PI) 3-kinase leurs sels pharmaceutiquement acceptables et des promédicaments de ceux-ci ; des compositions des nouveaux composés, soit seules, soit en combinaison avec au moins un agent thérapeutique supplémentaire, avec au moins un véhicule pharmaceutiquement acceptable, et des utilisations des nouveaux composés, soit seules, soit en combinaison avec au moins un agent thérapeutique supplémentaire, dans la prophylaxie ou le traitement de maladies caractérisées par l'activité anormale de facteurs de croissance, de protéine sérine/thréonine kinases et de kinases phospholipidiques, comprenant des maladies prolifératives, des maladies inflammatoires obstructives des voies respiratoires, des affections allergiques, des maladies auto-immunes et cardiovasculaires.

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