Pi3k/mtor kinase inhibitors

Details Pi3k/mtor kinase inhibitors Pi3k/mtor kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 413/04 (2006.01) A61K 31/519 (2006.01) A61K 31/5375 (2006.01) A61P 35/00 (2006.01) C07D 265/30 (2006.01) C07D 403/14 (2006.01) C07D 407/14 (2006.01) C07D 413/02 (2006.01) C07D 487/02 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2743015

6-morpholin-4-yl-pyrazolo[3,4-d]pyrimidine and 2-morpholin-4-yl-7H-pyrrolo[2,3- d]pyrimidine derivatives have unexpected drug properties as inhibitors of PI3 and/or mTOR kinases and are useful in treating disorders related to abnormal PI3K/mTOR activities such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine disorders and neurological disorders.

Linvention concerne des dérivés de 6-morpholin-4-yl-pyrazolo[3,4-d]pyrimidine et de 2-morpholin-4-yl-7H- pyrrolo[2,3-d]pyrimidine possédant des propriétés inattendues dinhibiteurs des PI3K et/ou mTOR kinases et utilisés pour traiter les troubles associés à lactivité anormale de PI3K/mT0R, tels que le cancer, les troubles immunitaires, les maladies cardio-vasculaires, les infections virales, les troubles du métabolisme/de lendocrine et les troubles neurologiques.

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