Picolinamide derivatives as kinase inhibitors

Details Picolinamide derivatives as kinase inhibitors Picolinamide derivatives as kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/444 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2734415

New picolinamide compounds, compositions and methods of inhibition of Provirus Integration of Maloney Kinase (PIM kinase) activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one PIM kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase- mediated disorder, such as cancer.

La présente invention concerne de nouveaux composés de picolinamide, des compositions et des procédés dinhibition de lactivité kinase dintégration de provirus de Maloney (kinase PIM) associée à la cancérogenèse chez un sujet humain ou animal. Dans certains modes de réalisation, les composés et compositions sont efficaces pour inhiber lactivité dau moins une kinase PIM. Les nouveaux composés et compositions peuvent être utilisés seuls ou en combinaison avec au moins un agent additionnel pour le traitement dun trouble véhiculé par une sérine/thréonine kinase ou un récepteur tyrosine kinase, tel que le cancer.

Affiliated with

Also associated with

Rating

Picolinamide derivatives as kinase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Picolinamide derivatives as kinase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Picolinamide derivatives as kinase inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1383771