C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/18 (2006.01) C12N 5/079 (2010.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01) C12N 15/09 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2704083
Nucleic acids encoding the neurotrophic protein known as pigment epithelium-derived factor (PEDF), a truncated version of PEDF referred to as rPEDF, and equivalent proteins, vectors comprising such nucleic acids, host cells into which such vectors have been introduced, recombinant methods for producing PEDF, rPEDF, and equivalent proteins, the rPEDF protein and equivalent proteins of rPEDF and PEDF-BP, -BX and BA, and the PEDF protein produced by recombinant methods. Effects and use of these variants on: 1) neuronal differentiation (neurotrophic effect), 2) neuron survival (neuronotrophic effect), and 3) glial inhibition (gliastatic effect) are described.
Becerra Sofia Patricia
Chader Gerald J.
Schwartz Joan P.
Taniwaki Takayuki
Department Of Health And Human Services The Government Of The United States Of America As Represented By
Department Of Health And Human Services (the) Government Of The United States Of America As Represented By The
Smart & Biggar
LandOfFree
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