Pigrl-1, a member of immunoglobulin gene superfamily

Details Pigrl-1, a member of immunoglobulin gene superfamily Pigrl-1, a member of immunoglobulin gene superfamily

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2241390

PIGRL-1 polyptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing PIGRL-1 polyptides and polynucleotides in the design of protocols for the treatment of Hyper-IgM Immunodeficiency (HIM), X-linked Severe Combined Immunodeficiency (XSCID), and IgA deficiency (IgA-D), among others and diagnostic assays for such conditions.

Divulgation de polypeptides et de polynucléotides PIGRL-1, ainsi que de méthodes de production de tels polypeptides par des techniques de recombinaison. Des méthodes d'utilisation des polypeptides et des polynucléotides PIGRL-1 dans la conception de protocoles pour le traitement de l'hyper-IgM (HIM), de l'immunodéficience combinée sévère liée à l'X (XSCID) et de la déficience en IgA (IgA-D), entre autres, de même que des épreuves diagnostiques pour ces conditions sont également dévoilées.

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