Pilosulin 2

Details Pilosulin 2 Pilosulin 2

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/35 (2006.01) C07K 14/435 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2232231

An isolated nucleic acid molecule including a nucleotide sequence encoding a polypeptide derived from ant venom and having biological activity of Pilosulin 2, wherein Pilosulin 2 is a polypeptide having the amino acid sequence from residues 49 to 75 shown in the Figure. An isolated polypeptide having biological activity of Pilosulin 2 and methods of lowering blood pressure in an animal using Pilosulin 2.

Cette invention concerne une molécule d'acide nucléique isolée contenant une séquence nucléotidique codant un polypeptide issu de venin de fourmis et possédant l'activité biologique de la pilosuline 2, ladite pilosuline 2 étant un polypeptide ayant la séquence d'acides aminés des résidues 49 à 75 montrés par la figure. L'invention concerne également un polypeptide isolé possédant l'activité biologique de la pilosuline 2 ainsi que des procédés permettant d'abaisser la pression sanguine chez un animal à l'aide de la pilosuline 2.

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