Pim kinase inhibitors and methods of their use

Details Pim kinase inhibitors and methods of their use Pim kinase inhibitors and methods of their use

C - Chemistry, Metallurgy

07

D

C07D 213/78 (2006.01) A61K 31/44 (2006.01) A61P 35/00 (2006.01) C07D 239/28 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2679659

New compounds, compositions and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine kinase or receptor tyrosine kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase- mediated disorder, such as cancer.

L'invention concerne de nouveaux composés, compositions et procédés d'inhibition de l'activité de kinase associée à la tumorigenèse chez un sujet humain ou animal. Dans certains modes de réalisation, des composés et compositions sont efficaces pour inhiber l'activité d'au moins une sérine/thréonine kinase ou tyrosine kinase réceptrice. Les nouveaux composés et compositions peuvent être utilisés soit seuls, soit en combinaison avec au moins un agent supplémentaire pour le traitement d'un trouble véhiculé par sérine/thréonine kinase ou tyrosine kinase réceptrice, tel qu'un cancer.

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