Pim kinase inhibitors and methods of their use

Details Pim kinase inhibitors and methods of their use Pim kinase inhibitors and methods of their use

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/4439 (2006.01) A61P 35/00 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2717388

The present invention relates to new compounds of Formulas (I) and (II), their tautomers, stereoisomers and polymorphs, and pharmaceutically acceptable salts, esters, metabolites or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the inhibition of Pirn kinase activity and/or the prophylaxis or treatment of cancer.

La présente invention porte sur de nouveaux composés représentés par les formules (I) et (II), sur leurs tautomères, stéréoisomères et polymorphes et sur leurs sels pharmaceutiquement acceptables, esters, métabolites ou promédicaments, sur des compositions des nouveaux composés conjointement avec des véhicules pharmaceutiquement acceptables et sur des utilisations des nouveaux composés, soit seuls soit en association avec au moins un agent thérapeutique supplémentaire, dans l'inhibition de l'activité de la Pim kinase et/ou la prophylaxie ou le traitement d'un cancer.

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